Comparison of the postoperative analgesic effectiveness and side effects of intravenous dexketoprofen trometamol and ibuprofen in patients undergoing abdominal hysterectomy
Erdem BAGCI, Gulen GULER, Kemal DEMIRTAS
Yozgat City Hospital, Clinic of Anesthesiology and Reanimation, Yozgat, Turkey
Giriş: Postoperative pain prolongs recovery and hospital stay if not treated effectively. In our study, we aimed to compare the postoperative analgesic efficacy and side effects of intravenous dexketoprofen trometamol and ibuprofen in patients undergoing abdominal hysterectomy.
Gereç ve Yöntem: 90 patients aged 18-65 years, ASA I-II, undergoing abdominal hysterectomy were randomly divided into three groups. At the transition to surgical closure; patients in ibuprofen group (Group I) administered 400 mg of ibuprofen in 100 ml of saline, patients in dexketoprofen group (Group D) administered 50 mg of dexketoprofen trometamol in 100 ml of saline, and the patients in placebo group (Group K) administered 100 ml of saline as infusion over 30 minutes. Patient controlled analgesia (PCA) prepared with morphine was started in all patients in the postoperative period. Hemodynamic parameters, Visual Analogue Scale (VAS) scores, morphine consumption and possible side effects were recorded at postoperative 0, 10, 30 minutes and 1, 2, 6, 12, 24 hours.
Bulgular: Demographic data of the patients and time to reach Aldrete recovery score ≥ 9 were similar between the groups. Morphine comsumption; it was observed that it was lower in Group I and Group D from the postoperative 6th hour compared to Group K, and in Group I it was decreased compared to Group D from the postoperative 6th hour (p < 0.005). When side effects were compared, it was seen that the number of patients with constipation in the placebo group was higher than in the study groups (p < 0.05), and other side effects were similar between the groups.
Tartışma ve Sonuç: We concluded that both drugs reduce morphine consumption in the treatment of postoperative pain in abdominal hysterectomies, ibuprofen provides more effective postoperative analgesia than dexketoprofen trometamol, and both drugs can be used safely in multimodal analgesia.
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