The effect of sugammadex on vitamin D level in rabbits under general anesthesia
Hatice Betül Altınışık, Tuğba Hünerel
Department of Anesthesiology and Reanimation, Canakkale Onsekiz Mart University, Medicine Faculty, Canakkale, Turkey
BACKGROUND AND AIM: Sugammadex reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effects of sugammadex on vitamin D levels, which has a steroid structure.
METHODS: This study conducted in Çanakkale Onsekiz Mart University Experimental Research Application and Research Center with approval of Local Animal Experimentation Ethics Committee. Fifteen adult male New Zealand White rabbits were randomly divided into three groups with five animals in each group: Group S (receiving sugammadex 16 mg/kg), Group N (receiving neostigmine 0.05 mg/kg), and Group C (control group). Intramuscular ketamine at a dose of 10 mg/kg was administered to all animals for premedication. Arterial cannulation and monitorization was applied to ears of rabbits to follow mean arterial pressure, blood gas values and collect blood samples. After induction, intravenous sugammadex 16 mg/kg was administered to rabbits in Group S and intravenous neostigmine 0.05 mg/kg and atropin 0.01 mg/kg were administered to rabbits in Group N. Serum vitamin D levels were measured before anesthesia, 20 minutes after anesthesia, and after 24 hours.
RESULTS: Mean±SD vitamin D levels before anesthesia, and 20 minutes and 24 hours after anesthesia were 4.42±0.60ng/ml, 4.93±0.72ng/ml, and 4.66±0.94ng/ml for Group S, 4.92±0.45ng/ml, 5.02±0.41ng/ml, and 5.41±0.56ng/ml for Group N, and 5.15±0.82ng/ml, 4.57±1.10ng/ml, and 5.21±1.05ng/ml for Group C, respectively. There were no statistically significant differences between the groups (p>0.05).
CONCLUSIONS: It was concluded that sugammadex has no effects on serum levels of vitamin D. This is the first study investigating the relationship between sugammadex and serum vitamin D levels. Further studies with higher samples sizes are needed to confirm our results.
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