Can Neutrophil-to-Lymphocyte or Platelet-to-Lymphocyte Ratio Be Used to Predict Postoperative Nausea and Vomiting in Breast Reduction
Onur Karaca, Güvenc Dogan,
Aksaray Üniversitesi Tıp FakültesiÇorum Hitit Üniversitesi Tıp Fakültesi
Background/Objective: PONV is one of the most frequently seen complications in the postoperative period. In several studies, NLR or PLR has been suggested as a parameter to be used in the diagnosis of the inflammatory diseases. However, the literature involves no information about this relationship for breast reduction. This study aims to investigate whether preoperative Neutrophil-lymphocyte ratio (NLR) or thrombocyte-lymphocyte ratio (PLR) was an indicator of postoperative nausea and vomiting (PONV) and identify its relationship with antiemetic use. Methods: In this study, hemogram values and antiemetic amounts taken within 24 hours were obtained retrospectively by scanning the files of the patients received breast reduction diagnosis and operation. The confounder effect was controlled using Propensity Score Matching analysis to distribute the case-control groups similarly. The Receiver Operating Characteristic (ROC) analysis was used to determine whether NLR and PLR could be a prognostic indicator for PONV prediction. Sensitivity, specificity values were calculated after the ROC analysis to determine the success of the cut-off points. Results: The success of NLR and PLR in discriminating PONV was found to be statistically significant (cutoff: 1.97, AUC=0.697, p=0.001, cutoff: 137.2, AUC=0.743; p< 0.001, respectively). In addition, the sensitivity of PLR (77.8%) in discriminating PONV was found to be higher in comparison to NLR (73.3%). Conclusions: One of the factors decreasing patient care quality and satisfaction is PONV. The results of this study showed that preoperative NLR and PLR could be taken into consideration in antiemetic use required for the prevention of postoperative nausea-vomiting in breast reduction operations.
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